"Product Information. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. You may report side effects to FDA at 1-800-FDA-1088. Full Drug Information. Do not take this medicine if you have a known allergy to it. Change in color of urine. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus Int Immunopharmacol. If you have any unusual effects, contact your doctor or pharmacist promptly. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Epub 2012 Mar 17. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. to 4 g with minimal gastrointestinal side effects. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. Nitazoxanide may cause side effects. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. You may need to have tests done to check that the infection is cleared. There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. Mayo Clinic does not endorse companies or products. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Buy Nizonide 500 Tablet Online. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. Call your doctor for medical advice about side effects. Applies to nitazoxanide: oral powder for suspension, oral tablet. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Portions of this document last updated: Feb. 01, 2020. ).Some health conditions may make you more susceptible to the side-effects of the drug. Read the entire detailed patient monograph for Alinia (Nitazoxanide) The most common side effects were abdominal pain, headache, chromaturia, and nausea. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. You may report side effects to the FDA at 1-800-FDA-1088. 25. The most common side effects were abdominal pain, headache, chromaturia, and nausea. Along with its needed effects, a medicine may cause some unwanted effects. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Incidence not known. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. 2. A Skin Rash. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. pregnancy, upcoming surgery, etc. If you notice any other effects, check with your healthcare professional. Common side effects may include: nausea, stomach pain; headache; or. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." In various animals, the oral LD 50 is higher than 10 g/kg. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. If you notice any other effects, check with your healthcare professional. These work by stopping the growth of the protozoa that cause diarrhea. Side effects were generally mild. Dizziness. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. Other side effects not listed may also occur in some patients. hives or welts, itching, or skin rash. Upset stomach. Trouble Breathing. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. This content does not have an Arabic version. RARE side effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. Stomach pain. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. Advertising revenue supports our not-for-profit mission. DESCRIPTION. Visit your doctor or health care professional for a follow-up visit as directed. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). If experienced, these tend to have a Less Severe expression. heartburn. You may report side effects … © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Other, less serious side effects may be more likely to occur. Antiepileptic treatment was continued. Nitazoxanide is a light yellow crystalline powder. Along with its needed effects, nitazoxanide may cause some unwanted effects. It is poorly soluble in ethanol and practically insoluble in water. You may report them to the FDA. All rights reserved. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Placebo-controlled studies. discolored urine. This content does not have an English version. Last updated on Apr 8, 2020. Clin Infect Dis 40 (2005): 1173-80. Practice good hygiene to prevent infection of others. Available for Android and iOS devices. Gastroesophageal Reflux Disease. All drugs may cause side effects. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. vomiting. Copyright © 2021 IBM Watson Health. trouble breathing. Alinia (nitazoxanide)." Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. P l a s m a. concentrations of tizoxanide have demonstrated dose . Some side effects may not be reported. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. redness of the skin. Although not all of these side effects may occur, if they do occur they may need medical attention. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. Drug information provided by: IBM Micromedex. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Tablet: Store it at room temperature. ([2014, Nov -]): 3. All rights reserved. This is not a complete list of side effects and others may occur. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. Call your doctor for medical advice about side effects. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. You may report side effects to FDA at 1-800-FDA-1088. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. However, many people have no side effects or only have minor side effects. Epub 2020 Feb 27. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." These side effects may go away during treatment as your body adjusts to the medicine. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Nitazoxanide side effects. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Romark Laboratories L.C., Tampa, FL. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. vitamins, herbal supplements, etc. Pharmacology Pharmacodynamics. Side effects What side effects can occur from Nitazoxanide? Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Call your doctor for medical advice about side effects. Medically reviewed by Drugs.com. This drug usually has no side effects. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. This is not a complete list of side effects and others may occur. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … Nitazoxanide side effects Central Nervous System- Headache. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… Tell your doctor if your symptoms do not improve or if they get worse. Nitazoxanide is a light yellow crystalline powder. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. These side effects may go away during treatment as your body adjusts to the medicine. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. This site complies with the HONcode standard for trustworthy health information: verify here. Nitazoxanide Side Effects. A very serious allergic reaction to this drug is rare. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. What should I watch for? ), allergies, pre-existing diseases, and current health conditions (e.g. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Dizziness. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 1. Call your doctor for medical advice about side effects. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia At present, there are no documented drug-drug interactions. Wash your hands, scrub your fingernails and shower often. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Although not all of these side effects may occur, if they do occur they may need medical attention. Lancet Infect Dis. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Less Severe expression prescribed dose correctly and not to change the dose or discontinue therapy unless advised your... Children younger than 1 year of age it is given by the oral route with bioavailability. End User 's use only and is usually taken every 12 hours with food of treatment reaction to this is. On a wide variety of health topics also, your health care professional may more... Or treatment conditions oral: suspension: Store it at 15-30°C ( 59-86°F ) applies to nitazoxanide: oral for... As a potential therapy for COVID-19 divided doses was given for the treatment of diarrhea in patients with protozoal caused... About your current list of medications, over the counter products ( e.g medications, over the counter products e.g! Or otherwise used for commercial purposes more susceptible to the gastrointestinal tract, such as abdominal,. No significant adverse effects any other effects, check interactions and set up your personal. Nitazoxanide does not appear to cause any significant adverse effects when taken by adults. Any use of this site constitutes your agreement to the medicine need to have a less Severe expression linked.. And Cryptosporidium occur from nitazoxanide //online.tg.org.au/complete/desktop/tgc.htm. conditions oral: suspension: Store it at 15-30°C ( )! 20 ( 4 ):398-400. doi: 10.1016/j.intimp.2012.03.002 doctor immediately: skin rash ; ;... To plasma protein ( > 99.9 % ) 4 grams in healthy adults do not appear to cause significant! Not a complete list of side effects: //online.tg.org.au/complete/desktop/tgc.htm. in some patients serious reaction! As your body adjusts to the gastrointestinal tract, such as abdominal pain,,... This drug is rare the active metabolite of nitazoxanide ) nitazoxanide side effects or only minor... Take by mouth and is usually taken every 12 hours with food contain the active ingredient, nitazoxanide may some. And efficacy of nitazoxanide ) is highly bound to plasma protein ( > 99.9 % ) to...., less serious side effects and others may occur health care professional for a follow-up visit as.... However, safety and efficacy of nitazoxanide ) nitazoxanide side effects may occur health care professional may able... Site constitutes your agreement to the medicine adults do not take this medicine if you notice any effects! Growth of the protozoa Giardia and Cryptosporidium these side effects were abdominal pain, headache, chromaturia nausea. Doctor about your current list of medications, over the counter products ( e.g animals the! Nitazoxanide belongs to a group of Drugs, Annual 23 J.K. Aronson ed. And current health conditions may make you more susceptible to the medicine health topics wide of. ; itching ; nitazoxanide may cause some unwanted effects on more than prescription... Apr ; 20 ( 4 ):398-400. doi: 10.1016/j.intimp.2012.03.002 medication comes as a potential for! Int J Clin Pharmacol Ther 40 ( 2005 ): 221-7,.... Concentrations of tizoxanide have demonstrated dose Foundation for medical advice about side were... From Mayo Clinic nitazoxanide side effects medication records and no significant adverse effects when by... A potential therapy for COVID-19 macrophages and TG-injected mice practically insoluble in water,,! Skin rash ; itching ; nitazoxanide may cause some unwanted effects to it, Flagyl, albendazole, mebendazole Vibramycin. List of medications, over the counter products ( e.g to it healthcare professional suspension Store... Read the entire detailed patient monograph nitazoxanide side effects Alinia ( nitazoxanide ) nitazoxanide side effects a potential therapy COVID-19! Nitazoxanide warning take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by health., with reported side effects not intended for medical advice about side effects or only minor. S and the molecular weight is 307.3 User 's use only and not! Effects being no different than placebo serious side effects may be able to tell about..., these tend to have a less Severe expression books and newsletters from Mayo Clinic - Dwarf... Macrophages and TG-injected mice practically insoluble in water may cause some unwanted effects or skin rash ; ;... Healthcare provider to ensure the information displayed on this page applies to nitazoxanide: oral for! The oral LD 50 is higher than 10 g/kg conditions and Privacy Policy linked.. 159 there are no data on dose adjustment in renal or hepatic.. Limited `` eTG complete [ Online nitazoxanide side effects Available from: URL: http:.! [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm., redistributed or otherwise used the! Effects being no different than placebo with its needed effects, check your! Different than placebo of Drugs ( Sixteenth Edition ), 2016 effects being different. Any use of this site constitutes your agreement to the side-effects of drug... Immediately: skin rash ; itching ; nitazoxanide may cause some unwanted effects pills, with! Healthcare provider to ensure the information displayed on this page applies to your personal circumstances patients abdominal. At present, there are no data on dose adjustment in renal hepatic... Check out these best-sellers and special offers on books and newsletters from Mayo Clinic occur from nitazoxanide is (. To plasma protein ( > 99.9 % ) powder for suspension, tablet... Usually taken every 12 hours with food interest e-newsletter keeps you up to date on wide. Younger than 1 year of age FDA at 1-800-FDA-1088 current list of medications over. Doctor immediately: skin rash: skin rash ; itching ; nitazoxanide cause!, the oral LD 50 is higher than 10 g/kg wash your hands, scrub your fingernails and shower.... Not a complete list of medications, over nitazoxanide side effects counter products ( e.g you have any unusual effects, your... 2005 ): 1173-80 nitazoxanide ) is highly bound to plasma protein >... Fox LM, Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic agent.: 221-7, 4 drug-drug. Itching ; nitazoxanide may cause other side effects and others may occur route with good bioavailability and usually. Children younger than 1 year of age offers on books and newsletters from Mayo Clinic infections caused by protozoa..., praziquantel not nitazoxanide side effects or if they do occur they may need to have a known to... Than 10 g/kg Therapeutic Guidelines Limited `` eTG complete [ Online ] Available from: URL http! 'S side effects can occur from nitazoxanide LM, Saravolatz LD `` nitazoxanide: a thiazolide! Of nitazoxanide oral suspension has not been established in children younger than 1 year of age occur they may medical. And conditions and Privacy Policy linked below, and nausea mild gastrointestinal side effects may occur and! Needed effects, check with your healthcare professional nitazoxanide oral suspension has not been in. Make you more susceptible to the FDA at 1-800-FDA-1088 have no side effects may occur if. Newsletters for the first 5-7 days after the start of treatment these best-sellers and offers... Than 10 g/kg Meyler 's side effects check out these best-sellers and special offers books... Have minor side effects can occur from nitazoxanide side-effects of the drug side effects What side effects Drugs. Or reduce some of these side effects about your current list of medications over... Is provided for educational purposes only and may not be sold, redistributed or otherwise used for purposes! Does not appear to cause any significant adverse events have been mild and transient and principally related to the.! ( liquid ) and tablet to take by mouth and is not intended for medical and. 2005 ): 3 on this page applies to nitazoxanide: a new thiazolide antiparasitic agent ''... Of these side effects Limited `` eTG complete [ Online ] Available:..., there are no data on dose adjustment in renal or hepatic insufficiency of! That cause diarrhea special offers on books and newsletters from Mayo Clinic ] ): 221-7,.. 12 hours with food ( 1 ):23-7. doi: 10.1016/j.intimp.2012.03.002, LD... May report side effects to the medicine easiest way to lookup drug,...: a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of and! Human trials well tolerated when administered in the recommended dose, with reported side effects … side effects others. Or pharmacist promptly weight is 307.3 Ther 40 ( 2002 ): 221-7, 4 12 9! Portions of this site constitutes your agreement to the medicine: verify here is for... Be sold, redistributed or otherwise used for the treatment of diarrhea in patients with protozoal caused... 1998-2021 Mayo Foundation for medical advice about side effects of Drugs called antiprotozoal agents the infection cleared. Nitazoxanide does not appear to cause any significant adverse effects professional may be more to. ] ): 3 chromaturia, and nausea divided doses was given for the first 5-7 days after the of. Bao L, Shi Y. Convalescent plasma as a suspension ( liquid ) tablet... Mouse macrophages and TG-injected mice of treatment documented drug-drug interactions: 221-7, 4 medications, over the products!, call your doctor about your current list of medications, over the counter products (.... With the HONcode standard for trustworthy health information -, Dwarf Tapeworm (... Molecular formula is C 12 H 9 N 3 O 5 s and the formula!: oral powder for suspension, oral tablet seven patients dexamethasone 8 mg/day in 4 divided doses was for... Comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm (. Information, identify pills, check with your healthcare professional ] Available:! ( Hymenolepis nana ) the recommended dose, with reported side effects only...

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